UVA researchers make a breakthrough in heart regeneration by identifying compounds that stimulate cardiomyocyte production.
The scientists found that the drugs acted similarly to promote cardiomyocyte production and did so without toxicity, which is a promising sign.New research from the University of Virginia Health scientists seeking drugs that can trigger heart tissue regeneration after a heart attack say their efforts show promise and may lead to future treatment options.
In their recent follow-up work, the researchers analyzed five of the 30 compounds they initially identified to determine how the compounds regenerate cardiomyocytes, which could help replace damaged heart tissue.The scientists say they gained a new understanding of how the compounds work in heart cells, which will be invaluable in developing drugs to treat or reverse heart damage and heart failure.
While promising, the scientists needed a better understanding of the drugs’ effects—how precisely they might stimulate cardiomyocyte production. The scientists were still determining how the compounds worked because they targeted proteins unrelated to previous studies on cardiomyocyte production.
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