Globally, approximately 58 million people are chronically infected with HCV, resulting in 290,000 annual deaths due to complications such as liver cirrhosis and liver cancer.
University of LübeckDec 6 2024 Although modern antiviral treatments achieve high cure rates, the global elimination of HCV remains a difficult goal due to inadequate early detection and limited treatment options. Indeed, HCV has been identified as one of the globally prioritized endemic pathogens for vaccine research and development in the World Health Organization's "Immunization Agenda 2030.
The innovative approach of the research Our research lays the foundation for a new generation of vaccines. We focus on overcoming the challenges posed by the viral diversity and immunological evasion of HCV," explains Prof. Krey. The team employed novel computational protein designs to mimic specific regions of the viral glycoproteins E1 and E2, known as neutralization epitopes.
Potential for vaccine development The results of this study provide a promising approach to overcoming previous failures in developing an effective HCV vaccine. This proof-of-concept approach not only brings us closer to an effective HCV vaccine but could also set new standards in vaccine development against this and other medically significant viruses." The study represents a significant milestone in vaccine research and could contribute to limiting the global spread of Hepatitis C in the long term. Future research aims to further enhance the efficacy of the immunogens.
Hepatitis C Vaccine Antibodies Cirrhosis Immune Response Liver Protein Research Virology Virus
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