Researchers at Georgia Tech and the University of Wisconsin have created a broad-spectrum vaccine capable of defending against various SARS-CoV-2 variants and related bat coronaviruses.
By Dr. Sanchari Sinha Dutta, Ph.D.Apr 17 2024 Scientists at the Georgia Institute of Technology and the University of Wisconsin, USA, have developed a broad-spectrum vaccine that can protect against severe acute respiratory syndrome coronavirus 2 variants as well as bat sarbecoviruses.Study: Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine.
Besides the emergence of a wide range of SARS-CoV-2 variants, an extensive reservoir of ACE2-binding sarbecoviruses has been identified in bats, which highlights the need for developing pan-sarbecovirus and pan-betacoronavirus vaccines. They analyzed the antigenic landscape and selected one bivalent formulation and two trivalent formulations to characterize their neutralizing antibody responses and protective efficacy in hamsters challenged with SARS-CoV-2 omicron variants as well as bat coronaviruses .
Regarding bat coronaviruses, all three formulations showed equivalent neutralizing efficacies against SHC014 and WIV1. In contrast, the Pfizer-BioNTech bivalent vaccine failed to induce detectable neutralizing antibody titers against any of the tested coronaviruses.
SARS SARS-Cov-2 Vaccine ACE2 Angiotensin Angiotensin-Converting Enzyme 2 Antibody Cell Cell Membrane Coronavirus Covid-19 Efficacy Enzyme Glycoprotein Immunization Lungs Membrane Nanoparticle Omicron Pandemic Protein Receptor Respiratory Severe Acute Respiratory Severe Acute Respiratory Syndrome Spike Protein Syndrome Technology
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