Next-gen antibiotic kills harmful bacteria, spares healthy gut microbes

The groundbreaking antibiotic called lolamicin kills harmful bacteria while preserving the beneficial microbes in the gut.

When given orally to mice with drug-resistant septicemia or pneumonia, lolamicin rescued 100% of the mice with septicemia and 70% of the mice with pneumonia.

Called lolamicin, the drug reduced or eliminated bacterial infections in mouse models of acute pneumonia. Crucially, it spared healthy microbes in the mouse gut. He maintained that gram-positive and gram-negative bacteria differ in the composition of their cell walls.Researchers claimed that the few drugs that fight gram-negative infections also eliminate beneficial gram-negative bacteria. Hence, they focused on a suite of drugs developed by the pharmaceutical company AstraZeneca to develop an antibiotic that doesn’t harm healthy gut microbes.

“The mouse microbiome is a good tool for modeling human infections because human and mouse gut microbiomes are very similar. Studies have shown that antibiotics that cause gut dysbiosis in mice have a similar effect in humans,” said Muñoz.

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