A University of Arizona College of Medicine – Phoenix researcher was recently awarded a $1.9 million National Institutes of Health grant to study the molecular mechanisms of how dilated cardiomyopathy progresses to heart failure, which could eventually lead to better preventive and treatment options for heart failure.
University of Arizona Health SciencesSep 27 2024
Inna Gladysheva, PhD, a research professor in the Department of Internal Medicine and a member of the Translational Cardiovascular Research Center at the College of Medicine – Phoenix, will use the grant to advance her research into the impact of proteolytic enzymes' networks in the progression of DCM to overt heart failure and examine how the protease-driven impairment of neurohumoral biological pathways impacts this progression.
"Our exciting discovery suggests and offers a new paradigm in heart failure management. The long-term project goal is to translate knowledge into novel therapeutic strategies needed to prevent or treat the progression of heart failure, improving its outcomes and the duration of patients' lives," Gladysheva said.
Related Stories"We also investigate the impacts of pharmacological and non-pharmacological approaches such as lifestyle choices on cardiac function and edema with presided consideration of sex and age-related differences," Gladysheva said. "Our translational studies contribute to understanding the molecular mechanisms forcing the progression of cardiac dysfunction and edema development.
Heart Failure Research Cardiomyopathy Edema Medicine
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