Researchers at Washington University School of Medicine in St. Louis are receiving $7.5 million from the National Institutes of Health to investigate a form of dementia caused by cerebral small vessel disease. The team will use cutting-edge technologies to analyze brain tissues and identify potential drug targets to mitigate the damage caused by this disease.
Research ers at Washington University School of Medicine in St. Louis have been awarded $7.5 million from the National Institutes of Health ( NIH ) to investigate a form of dementia caused by cerebral small vessel disease, the second-leading cause of dementia after Alzheimer's disease.
The grant funds the Vascular Contributions to Cognitive Impairment and Dementia (VCID) Center, which is a National Institute of Neurological Disorders and Stroke 'Center Without Walls' initiative that will coordinate researchers at six sites across the U.S. The WashU Medicine team will apply new magnetic resonance image-processing tools and other cutting-edge 'multi-omic' technologies (a technique that looks at proteins, genes, metabolites and other complex systems together) to analyze cerebrospinal fluid and brain tissues from human and animal models to precisely map mRNA within cells affected by cerebral small vessel disease (CSVD). The long-term goals are to track biomarkers that can be used to identify the onset of CSVD-linked conditions and to locate targets for drugs that might mitigate or protect against the damage caused by the disease. Three co-investigators are leading the effort at WashU Medicine: Jin-Moo Lee, MD, PhD, the Andrew B. & Gretchen P. Jones Professor in Neurology and head of the Department of Neurology; Carlos Cruchaga, PhD, the Barbara Burton & Reuben M. Morriss Professor of Psychiatry; and Manu Goyal, MD, an associate professor of radiology in the Mallinckrodt Institute of Radiology at WashU Medicine. CSVD occurs when small blood vessels in the brain are damaged and lose their ability to change caliber to accommodate greater or lesser amounts of blood as needed by the brain. When the vessels lose this ability, it can lead to a lack of blood flow to regions of the brain, a condition known as ischemi
DEMTNCIA CEREBRAL SMALL VESSEL DISEASE NIH RESEARCH WASHINGTON UNIVERSITY SCHOOL OF MEDICINE
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