Study demonstrated a 90% effectiveness of nirsevimab in preventing RSV-associated hospitalizations in infants, with a significant finding being the timely vaccination's role in offering protection.
By Vijay Kumar MalesuMar 10 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in MMWR Morbidity and Mortality Weekly Report, a group of researchers assessed the effectiveness of nirsevimab in preventing Respiratory syncytial virus -associated hospitalizations among infants during their first RSV season between October 1, 2023, and February 29, 2024.
Background RSV leads to significant hospitalization among United States infants, with 50,000–80,000 cases yearly in children under five. The highest risks are in the first months of life, decreasing as children grow. In August 2023, the Centers for Disease Control and Prevention endorsed nirsevimab for infants under 8 months for their first RSV season and certain children 8–19 months old.
Using a test-negative, case-control design, the study evaluated nirsevimab's effectiveness in preventing RSV-associated hospitalizations. Cases involved infants with positive RSV tests, while controls were RSV-negative. Effectiveness was considered for vaccines administered more than seven days before symptoms appeared.
Related StoriesA notable finding from the study was the higher incidence of nirsevimab receipt among infants with high-risk medical conditions compared to those without such conditions, with percentages standing at 46% and 6%, respectively, indicating a significant correlation . This suggests a targeted approach in administering nirsevimab to those infants deemed at greater risk of severe RSV disease.
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