NmCV-5 vaccine safety and immunogenicity against bacterial meningitis in Mali and Gambia NEJM vaccine immunogenicity meningitis africa maliandgambia vaccinesafety publichealth
By Pooja Toshniwal PahariaMay 30 2023Reviewed by Lily Ramsey, LLM In a recent study published in The New England Journal of Medicine, researchers evaluated the safety and non-inferiority of the pentavalent meningococcal NmCV-5 vaccine compared to the World Health Organization -prequalified MenACWY-D quadrivalent meningococcal vaccine.
Meningococcal A serogroup infections have been eliminated; however, other serotypes continue to cause diseases, warranting the development of potent, cost-effective, and multivalent-type meningococcal vaccines. About the study In the present study, researchers presented Phase III trial results of the NmCV-5 vaccine concerning vaccine immunogenicity and safety compared to the MenACWY-D vaccine in Gambia and Mali.
They compared immune responses against serogroup X by NmCV-5 vaccinees to the least response by MenACWY-D vaccinees. In addition, data on solicited and unsolicited adverse events were obtained to assess vaccine safety. The difference in seroresponses between the groups ranged between 1.20 percentage points and 21 percentage points .
GMTs four weeks after MenACWY-D vaccination ranged between 1,855 for the C serogroup and 12,295 for the W serogroup. The adjusted geometric mean titer ratio obtained after comparing the GMTs for the X serogroup among NmCV-5 vaccinees to those for the C serogroup among MenACWY vaccinees was 10.
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