Non-TNF inhibitor biologic disease-modifying antirheumatic drugs did not appear to increase the risk for cancer in patients with RA in a real-world cohort study.
with non-tumor necrosis factor inhibitor biologic disease-modifying antirheumatic drugs may not pose an increased risk for cancer, compared with TNFis and conventional synthetic DMARDs.By utilizing information from Danish registers , researchers compared the risk for cancer in 14,944 patients with RA who were initiated on non-TNFi bDMARDs and bDMARD-naive groups . However, the results were not statistically significant.
Treatment with rituximab may be associated with a lower risk for hematologic cancers than for TNFi-treated or bDMARD-naive groups , although the findings did not show statistical significance.The authors wrote, "bDMARD-associated cancer risk remains a clinically important research question, and more future studies specifically investigating non-TNFi bDMARDs in terms of cancer risk in patients with RA are warranted.
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