New data from a prospective study support non-radical surgery (simple hysterectomy or cone biopsy) for early-stage low-risk cervical cancer.
or cone biopsy plus pelvic lymphadenectomy) appears safe with no lasting negative impact on quality of life, according to results of the
Due to screening in developed countries, a large proportion of cervical cancers are discovered at an early stage. Treatment of these cancers with radical surgery is associated with high cure rates but significant adverse effects on quality of life, said Covens, who is with the University of Toronto, Toronto, Ontario, Canada.
The primary objectives were to assess changes in functional outcomes of quality of life , using validated instruments. Findings were based on 55 patients who underwent cone biopsy and 113 who underwent simple hysterectomy. He also reported 16 pregnancies in 15 patients who had undergone cone biopsies; 12 of these were successful, and there were four early pregnancy losses.Study discussant Kristin Bixel, MD, with The Ohio State University, Columbus, Ohio, said the data are "impressive" and clearly show that non-radical surgery has "minimal impact on bladder/bowel function, with no long-term differences from baseline.
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