Research in nonhuman primates is opening the possibility of testing treatments for the early stages of Alzheimer’s and similar diseases, before extensive brain cell death and dementia set in.
University of California - DavisJun 26 2024 A study published June 21 in Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association shows up to a six-month window in which disease progress could be tracked and treatments tested in rhesus macaques.
The sick neurons then cause an inflammatory response mediated early on by microglial cells. Eventually, neurons die, leaving neurofibrillary tangles of tau protein, one of the key markers of Alzheimer’s and other dementing illnesses. Six months of measurable disease progression The researchers injected a vector carrying DNA for two mutated tau proteins into the entorhinal cortex of 12 monkeys. The entorhinal cortex is a key brain region that is involved with memory and is where the disease usually originates in human Alzheimer’s.
The results show that in this model, there is a window of at least two to six months where the progress of the disease can be measured. That opens the possibility of preclinical testing of interventions that target the tau protein.
Brain Cell Cell Cell Death Cortex Dementia Imaging Inflammation Neurology Neurons Pathology Protein Research Tau Protein
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Research team develops searchable database for Alzheimer's researchA searchable database is now ready to help study Alzheimer's disease.
Read more »
New research points to possibility for testing to explore early-stage Alzheimer's diseaseResearch in nonhuman primates is opening the possibility of testing treatments for the early stages of Alzheimer's and similar diseases, before extensive brain cell death and dementia set in.
Read more »
Research suggests potential targets for prevention and early identification of psychotic disordersA new study by the Centre for Addiction and Mental Health (CAMH), titled 'Mental health service use before first diagnosis of a psychotic disorder' and published in JAMA Psychiatry, found that nearly 75% of young Ontarians with a psychotic disorder had at least one mental health service visit within the three years prior to their first diagnosis...
Read more »
New report highlights the urgent need for gender-specific cardiovascular research and careCardiovascular disease is the leading cause of death for women, and gaps in care and access persist between women and men.
Read more »
Research team refining at-home sleep apnea detection device to help with more efficient diagnosis, treatmentIn continuing research, West Virginia University researchers will put a sleep apnea detection device at the fingertips or wrists of patients, facilitating early diagnosis and treatment of the disease.
Read more »
Shaking up weight loss: Research finds meal replacement offering stacks upNew analysis has found CSIRO's Fast Start meal replacement shakes offering, delivered as part of the CSIRO Total Wellbeing Diet online program, has helped Australians kick start their weight loss journey, with 98% of members losing weight in 12 weeks.
Read more »