One of the first signs of bladder cancer can be blood in the urine (hematuria). Investigators developed and analyzed the results of a streamlined and simplified DNA-based urine test to improve the accuracy of early detection of bladder cancer in patients with hematuria.
ElsevierJun 20 2024 One of the first signs of bladder cancer can be blood in the urine . Investigators developed and analyzed the results of a streamlined and simplified DNA -based urine test to improve the accuracy of early detection of bladder cancer in patients with hematuria.
Aberrant DNA methylation has long been recognized as a promising diagnostic biomarker in various cancer types, including bladder cancer. Therefore, to improve bladder cancer detection accuracy using urine cytology, Dr. An and co-investigators had previously developed a novel molecular diagnostic tool to measure proenkephalin methylation levels using two steps of real-time PCR in urine DNA to detect primary bladder cancer in patients with hematuria.
Investigators tested the sensitivity and specificity of EarlyTect BCD, a single biomarker test. Results were comparable to or even better than the reported performance of other multi-biomarker tests. In a retrospective training set , an optimal cutoff value was determined to distinguish bladder cancer from non-bladder cancer, resulting in a sensitivity of 87.3% and a specificity of 95.2%.
Dr. An comments, "There is a rational imperative to accurately diagnose bladder cancer patients through noninvasive molecular diagnostic methods, particularly those with high grade noninvasive papillary carcinoma and higher stages, who exhibit a heightened propensity for disease progression.
Bladder Cancer Cancer Hematuria Urine Test Biomarker Blood Carcinoma Cystoscopy Cytology Diagnostic Diagnostics DNA Molecular Diagnostics
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