A pensioner, a man in his 20s and a woman in her 50s all died in the collision between two cars. A woman in her 20s and four children are being treated in hospital for their injuries.
Police are appealing for information from anyone who may have witnessed the crash, or who may have dashcam footage of the accident.
SDLP Mid Ulster MLA Patsy McGlone said:"The community is devastated this evening following news of a fatal collision on the Dungannon Road. In a tweet, Ulster Unionist Party leader Doug Beattie said:"I just can't imagine the horror those who survived have endured and the scene faced by the emergency services. Life is so precious and so fragile."
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