The first trial of a novel strategy for removing cholesterol from patients' arteries did not reduce the risk of death, heart attack or stroke within three months of a prior heart attack, according to research presented at the American College of Cardiology's Annual Scientific Session.
Apr 8 2024American College of Cardiology The first trial of a novel strategy for removing cholesterol from patients' arteries did not reduce the risk of death, heart attack or stroke within three months of a prior heart attack , according to research presented at the American College of Cardiology 's Annual Scientific Session. However, the findings suggest that the strategy may be beneficial with longer follow-up.
People who have had a heart attack are at high risk for another one, especially during the next 90 days, Gibson said. This study was the first in which patients received an infusion of ApoA-I, a component of HDL cholesterol, shortly after a heart attack, with the aim of stabilizing coronary plaque and reducing adverse cardiovascular events. The investigational drug CSL112 used in the study is a form of ApoA-I that's extracted from human plasma, the liquid component of blood.
"We know that in the setting of a heart attack, when the HDL cholesterol is good at getting a lot of cholesterol out of the arteries, that results in better outcomes for patients," he said. The study's primary endpoint was the time to the first occurrence of a major adverse cardiovascular event at 90 days. Secondary endpoints included the time to the first occurrence of a MACE within six months and one year and of each specific event within 90 days, six months and one year.
Future research will focus on identifying high-risk patients who might benefit from this approach, he said.
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