A drug-carrying molecule designed to cure disease by slipping past the lung's natural defenses offers new hope for people with chronic or deadly respiratory diseases, say its creators, researchers in assistant professor Liheng Cai's Soft Biomatter Lab at the University of Virginia School of Engineering and Applied Science.
University of Virginia School of Engineering and Applied ScienceAug 22 2024 A drug-carrying molecule designed to cure disease by slipping past the lung's natural defenses offers new hope for people with chronic or deadly respiratory diseases, say its creators, researchers in assistant professor Liheng Cai's Soft Biomatter Lab at the University of Virginia School of Engineering and Applied Science.
Sneaking past our defenses Our lungs have layers of protection that trap and transport pathogens or inhaled particles out of the respiratory system to prevent us from getting sick. Unfortunately, those same barriers also stop medicine from reaching targeted cells, making it hard to treat diseases such as asthma, chronic obstructive pulmonary disease and pulmonary fibrosis." The new polymer is called bottlebrush polyethylene glycol, or PEG-BB.
To test their hypothesis, the team cultured human airway epithelial cells in their device. They introduced fluorescent PEG-BB molecules into the cells from two directions. A string of recent successes "The micro-human airway is basically an equivalent home for the cells to grow," Huang said.
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