Researchers performed a case-control study to compare metabolic changes between individuals homozygous for a loss-of-function genetic variation in small integral membrane protein 1 (SMIM1) and the general population.
By Pooja Toshniwal PahariaReviewed by Danielle Ellis, B.Sc.Jun 25 2024 In a recent study published in Med, researchers performed a case-control study to compare metabolic changes between individuals homozygous for a loss-of-function genetic variation in small integral membrane protein 1 and the general population.
About the study In the present study, researchers evaluated the impact of SMIM1 absence on human health using phenotypic population biobanks to explore genetic susceptibility to overweight or obesity. Researchers examined UK Biobank data to see if the SMIM1 LoF mutation was linked to any features other than those seen in the blood. They collected blood samples and health data from 25 British SMIM1-/- individuals and compared them to 180 individuals who contained at least one reference allele for variation rs566629828.
Allele Blood Cell Dyslipidemia Gene Genes Hormone Hospital Insulin Insulin Resistance Membrane Metabolic Syndrome Mutation Obesity Protein Research Syndrome Thyroid
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