Researchers from SMART and NUSTEP have developed a method to improve the ability of mesenchymal stromal cells (MSCs) to generate cartilage tissue by adding ascorbic acid (AA). They also discovered that micro magnetic resonance relaxometry (µMRR), a novel process analytical tool, can monitor MSC quality expansion.
Singapore-MIT Alliance for Research and Technology Oct 18 2024 Researchers from the Critical Analytics for Manufacturing Personalized-Medicine Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology , MIT’s research enterprise in Singapore, alongside collaborators from the National University of Singapore Tissue Engineering Programme , have developed a novel method to enhance the ability of mesenchymal stromal cells to generate cartilage tissue by adding ascorbic...
The heterogeneity of MSCs can lead to variations in their biological behavior and treatment outcomes. While large-scale MSC expansions are required to obtain a therapeutically relevant number of cells for implantation, this process can introduce cell heterogeneity.
Using novel PATs developed by CAMP, the researchers explored the potential of metabolic modulation in both short- and long-term harvesting and reseeding of cells. To enhance their chondrogenic potential, they varied the nutrient composition, including glucose, pyruvate, glutamine, and ascorbic acid .
The research also demonstrates the potential of the process analytical tool developed by CAMP, micromagnetic resonance relaxometry – a miniature benchtop device that employs magnetic resonance imaging imaging on a microscopic scale – as a process-monitoring tool for the expansion of MSCs with AA supplementation. Originally used as a label-free malaria diagnosis method due to the presence of paramagnetic hemozoin particles, μMRR was used in the research to detect senescence in MSCs.
Cartilage Regeneration Mesenchymal Stromal Cells Ascorbic Acid Micro Magnetic Resonance Relaxometry Cell Therapy
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