A new PET radiotracer enables same-day imaging of the important gastrointestinal cancer biomarker known as Claudin18.2 (CLDN18.2).
Jun 6 2024Society of Nuclear Medicine and Molecular Imaging A new PET radiotracer enables same-day imaging of the important gastrointestinal cancer biomarker known as Claudin18.2 . Uptake of the radiotracer, 68Ga-NC-BCH, was found to correlate significantly with CLDN18.2 expression, a promising finding that could allow oncologists to optimize treatment for patients and monitor their response. This research was published in the June issue of The Journal of Nuclear Medicine .
The protein CLDN18.2 is highly expressed in gastrointestinal cancers and several forms of CDLN18.2-targeted therapies are currently undergoing clinical trials. There is no standard test for CLDN18.2, however, and most detection methods involve immunohistochemistry, an invasive process that covers only a small amount of tissue and does not reflect the heterogeneity of CLDN18.2 expression in tumors.
68Ga-NC-BCH was stably prepared and demonstrated good radiochemical properties. The radiotracer exhibited rapid blood clearance, high affinity for CLDN18.2, and high specific uptake in CLDN18.2-positive cells and xenograft mouse models. In patients, 68Ga-NC-BCH displayed high uptake in the stomach and kidney and slight uptake in the pancreas. Compared with 18F-FDG, 68Ga-NC-BCH identified more lesions in the lymph nodes and peritoneum, the most common metastatic sites of advanced gastric cancer.
Cancer Cancer Biomarker Gastrointestinal Cancer Carcinogenesis Colon Colon Cancer CT Gastric Cancer Hospital Imaging Laboratory Lymph Node Lymph Nodes Medicine Molecular Imaging Nuclear Medicine Research
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