What happens to the dopaminesystem when we experience aversive events? elife
). For this purpose, a moveable grid floor that covered one quadrant of the open field was installed. Ten food pellets were placed between the grid-floor bars before the rats were placed in the middle of the open field for each 10 min session.
For the analysis of the first 30 conditioning trials, we compared the average dopamine concentration during the cue and the WN epoch to baseline . To analyze trials with different contingencies , we compared average dopamine during the relevant epochs with average dopamine in the respective epochs in immediately preceding trials 5 s cue/6 s WN pairings , during which dopamine decreases had stabilized and were unaffected by different contingencies.
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