A groundbreaking project brings together leading experts from NYU Langone Health, NYU Grossman School of Medicine, and other institutions across the U.S. to advance vision-restoring whole-eye transplants.
Research ers from NYU Langone Health and NYU Grossman School of Medicine are collaborating on a groundbreaking project to make vision-restoring whole- eye transplant s a reality. This ambitious undertaking will bring together over 40 scientists, doctors, and industry experts from across the country to tackle this complex challenge. NYU Langone has a unique history in this field, having successfully performed the world's first whole-eye and partial-face transplant in 2023.
While the transplanted eye has not yet regained vision, a significant portion of its light-sensitive nerve cells survived, providing valuable insights for future research. This new project, funded by the Advanced Research Projects Agency for Health (ARPA-H), will build upon these initial findings.Teams from NYU Langone and NYU Grossman School of Medicine will focus on several key areas: refining surgical protocols for eye transplantation, molecularly profiling the transplanted eye to understand its survival mechanisms, and identifying biomarkers for rejection. They will also contribute scientific knowledge gained from their experience in preserving donated eyes, regenerating donor optic nerves, and integrating them into the recipient's brain. The project, titled 'Viability, Imaging, Surgical, Immunomodulation, Ocular preservation and Neuroregeneration (VISION) Strategies for Whole Eye Transplant,' reflects the comprehensive nature of the collaborative effort.Leading the initiative are principal investigator Jeffrey Goldberg, MD, PhD, Blumenkranz Smead professor and chair of ophthalmology at the Byers Eye Institute at Stanford University, and co-director José-Alain Sahel, MD, professor and chair of the Department of Ophthalmology at the University of Pittsburgh. The biggest hurdle for the team is restoring functional vision, which requires figuring out how to regenerate the optic nerve, the vital link between the eye and the brain. Achieving this goal would be a major breakthrough, potentially transforming the lives of countless individuals with vision loss. The project's success hinges on the combined expertise of ophthalmologists, radiologists, neuroscientists, and plastic surgeons, working together to develop new surgical techniques, artificial intelligence integrations, regenerative medicine breakthroughs, and strategies to minimize rejection. The ARPA-H funding is a significant investment in this ambitious endeavor, demonstrating the potential impact of whole-eye transplantation
EYE TRANSPLANT VISION RESTORATION NYU LANGONE RESEARCH BIOTECHNOLOGY TRANSPLANTATION OPTOMETRY NEUROSCIENCE
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