Although more than 40% of cancers are considered obesity-related, excess weight is often just a contributing risk factor, leaving uncertainty about the role weight plays in cancer risk.
According to the Centers for Disease Control and Prevention , over 684,000 Americans are diagnosed with an"obesity-associated" cancer each year.
"What we know is that, consistently, a higher body mass index — particularly in the obese category — leads to a higher risk of multiple cancers," saidin 2016, the International Agency for Research on Cancer analyzed over 1000 epidemiologic studies on body fat and cancer. The agency pointed to over a dozen cancers, including some of the most common and deadly, linked to excess body weight.
Regarding direct effects, preclinical research has pointed to multiple ways in which excess body fat could contribute to cancer, saidOne broad mechanism to help explain the obesity-cancer link is chronic systemic inflammation because excess fat tissue can raise levels of substances in the body, such as tumor necrosis factor alpha and interleukin 6, which fuel inflammation.
With other cancers, the risk increases for those with severe obesity compared with a normal BMI were far more modest: 10% for ovarian cancer, 30% for colorectal cancer, and 80% for kidney and stomach cancers, for example. For postmenopausal breast cancer, every five-unit increase in BMI was associated with a 10% relative risk increase.
But while obesity trends probably partly explain the rise in early-onset cancers, there is likely more to the story, Meyerhardt said.
Obese Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Cancer Risk
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
How Metabolic Syndrome, Obesity Impact Breast Cancer Incidence, Mortality RiskNew data from the Women's Health Initiative revealed that metabolic syndrome and obesity each have different associations with breast cancer incidence and mortality risk in postmenopausal women.
Read more »
Colon cancer rising in young Americans, now leading cause of cancer deathColon cancer rates are on the rise among young Americans and the disease is now the leading cause of cancer death for men under 50 and the second most deadly cancer for women under 50.
Read more »
Conquering cancer: Cleveland Marathon runner turned cancer patient shares survival storyJohn Johnson is an avid runner. He spent countless hours training for last year’s Cleveland Marathon.
Read more »
Mother rings 'Cancer Bell' to celebrate victory over ovarian cancerAutumn Gray gathered with family, friends, and medical team at Kaiser Permanente Oncology Unit.
Read more »
Poorer English Breast Cancer Survivors Face Higher Second Cancer RiskI'm a former correspondent for award-winning health policy publication, the Health Service Journal. My work exposing PPE shortages in hospitals during the pandemic was recognized as 'Excellence in Reporting Coronavirus' by Press Gazette. I've been a journalist for nine years and have also written for Newsweek and Metro.co.uk.
Read more »
Children receiving cancer treatment at Texas cancer center treated to special prom party paloozaAt least 80 children and their families got the full prom experience at MD Anderson Cancer Center on Saturday.
Read more »