Obese pregnant women infected by Zikavirus have impaired immuneresponse, shows study
Placental tissue from mothers with and without obesity shows a similar profile of transcriptional antiviral factors’ expression. Placentas, collected after delivery, of full-term pregnant women, were assessed from the non-obese and obese groups. The mRNAs of the antiviral factors STING, RIG1, MxA, and ISG15, Toll-like receptors and the intracellular pathway of activation, TLR3, TLR7, and IRF3, and interferons, IFNA, IFNB, and IFNL, were evaluated by RT qPCR.
The type of delivery , gestational trimester of ZIKV infection , gestational age, newborn weight, and length , and newborn’s abnormalities and mother’s comorbidities was obtained from the maternity hospitals. The bars represent the median and interquartile range of the values.Altered placental antiviral factors’ expression triggered by ZIKV infection in gestational obesity. Placentas, collected after delivery, from ZIKV+ infected mothers were separated into the non-obese and obese groups.
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