Obesity pathogenesis: Unanswered questions and future directions

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Obesity pathogenesis: Unanswered questions and future directions
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Prof. John Speakman from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences, alongside Prof. Kevin Hall from the National Institutes of Health (U.S.), Prof. Thorkild Sorensen from the University of Copenhagen and Prof. David Allison from Indiana University (U.S.), has published a perspective article on potential mechanisms of obesity pathogenesis.

It was based on an academic conference held by The Royal Society, with experts and scholars in the field of obesity research discussing the potential pathogenesis of obesity.Governments around the world have struggled to curb the rising obesity rates, with no signs of improvement. Despite strategies that have often focused on exercise promotion and junk food advertising bans, the issue proves more intricate than initially thought.

Recent advances in obesity research have been significant. Leptin, a hormone produced by fat cells, plays a pivotal role in regulating food consumption by triggering brain signals. The traditional view of adipose tissue as a passive storage unit has shifted to recognizing its active role in producing hormones that impact the entire body. However, despite these strides, the global still struggle against the expending waistline.

What mechanisms drive the impact of the food environment on body weight regulation? This encompasses broader environmental factors like social influences and the built environment.

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