Researchers have discovered a new avenue of cell death in Alzheimer's disease and vascular dementia.
A new study, led by scientists at Oregon Health & Science University and published online in the journal Annals of Neurology on Aug. 21, reveals for the first time that a form of cell death known as ferroptosis -; caused by a buildup of iron in cells -; destroys microglia cells, a type of cell involved in the brain's immune response, in cases of Alzheimer's and vascular dementia.
Back has long studied myelin, the insulation-like protective sheath covering nerve fibers in the brain, including delays in forming myelin in premature infants. The new research extends that line of work by uncovering a cascading form of neurodegeneration triggered by deterioration of myelin. They made the discovery using a novel technique developed by the study's lead author Philip Adeniyi, Ph.D., a postdoctoral researcher in Back's laboratory.
Given the intense scientific focus on the underlying cause of dementia in older adults, Back called it amazing that researchers hadn't made the connection to ferroptosis until now.
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