Scientists have reviewed literature and conducted a meta-analysis to explore the high mortality rates associated with Chronic Pulmonary Aspergillosis (CPA) despite antifungal treatments. The study highlights older age, specific disease subtypes, and underlying conditions like malignancy as major contributors to higher mortality risks.
By Dr. Priyom Bose, Ph.D.Reviewed by Danielle Ellis, B.Sc.Dec 3 2024 Older age, specific disease subtypes, and underlying conditions like malignancy identified as major contributors to higher mortality risk s
People with diabetes, tuberculosis, or low-dose systemic corticosteroid dependence are susceptible to CPA. A recent study revealed the possibility of an increase in CPA mortality by 20% in India. The annual incidence of CPA has been estimated to be 1.8 million cases with 3,04,000 deaths. In tuberculosis-endemic countries, CPAs are often misdiagnosed as sputum-negative pulmonary tuberculosis, which could be attributed to their increased prevalence cases and mortality rates.
Subgroup analyses were conducted to analyze the overall heterogeneity in 1-year and 5-year CPA mortality, and random-effects meta-analyses were conducted to estimate pooled mortality rates. Related StoriesIn comparison to Europe, a greater prevalence of post-tuberculosis lung disease has been documented in South-East Asia. However, chronic obstructive pulmonary disease was found to be highest in European cohorts, followed by Western Pacific cohorts. A higher number of non-tuberculous mycobacterial lung disease cases has been reported from the Western Pacific region.
In the IPD cohort, a total of 676 patients were diagnosed with tuberculosis, whose mean age was 35.7 years. The majority of these patients had at least one underlying comorbidity. Diabetes, chronic corticosteroid use, radiotherapy, HIV infection, and chronic alcoholism were found to be the risk factors for patients with SAIA. Pulmonary tuberculosis, followed by COPD, was found to be a predisposing condition that leads to increased mortality rates in patients with CPA.
CPA Mortality Risk Antifungal Treatments Chronic Pulmonary Aspergillosis Meta-Analysis
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