A new study by the University of Bristol reveals that age and gender can affect inflammation caused by gene therapy treatments for eye diseases, potentially leading to damage. The findings highlight the need for personalized treatment to reduce risks and ensure better outcomes for all patients.
University of BristolFeb 10 2025 Older women could be vulnerable to harmful inflammation from new gene therapies to treat incurable eye diseases, new research has found. The University of Bristol-led study, published in Molecular Therapy, reveal how age and gender affects inflammation caused by gene therapy treatments and could cause damage to the eye.
Inflammation is a major challenge for this type of treatment because it can limit its effectiveness. Researchers at Bristol wanted to better understand how the eye reacts to the methods used to deliver the therapy, not the disease itself, to improve safety and effectiveness of future treatments. To improve the safety and effectiveness of these gene therapies the researchers wanted to better understand these responses so they can develop management strategies. To test this theory, the research team compared, in animal models, how both male and female eye cells of different ages responded to AAV gene therapy.
As the cells aged, researchers found the inflammation lasted longer and was more severe in both genders. While cells from older males had a consistent immune response pattern, the cells from older females had a much stronger stress and inflammation response that was linked to signs of retinal damage.
GENETHERAPY INFLAMMATION EYE DISEASES WOMEN's HEALTH AGING
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