One-day keto diet boosts energy expenditure, exogenous ketones have little effect ketogenicdiet energyexpenditure exogenousketones appetiteperception clinicaltrial nutritionresearch healthyeating weightmanagement ESPENorg
By Dr. Priyom Bose, Ph.D.May 29 2023 A high-fat ketogenic diet promotes higher total energy expenditure , which leads to weight loss. In addition, the appetite suppressant effects of acetoacetate and ketone bodies beta-hydroxybutyrate promote weight loss. A previous study revealed that 14 days of KD caused spontaneous weight loss in obese and type 2 diabetic patients. However, there have been contradictory findings regarding the effect of a KD on TEE and appetite perception.
Background Even though KD has many health benefits, including lowering glycemia and insulin levels, it has been associated with some ill effects, such as an increase in low-density lipoprotein cholesterol. In addition, long-term adherence to KD could be difficult due to restricted food choices and undesirable side effects, such as gastrointestinal problems. Recently, intermittent fasting or short-term diets have gained much popularity.
About the Study A total of 8 healthy adults, equally representative of men and women, were recruited into this randomized crossover study. All participants were 20 to 35 years old and had low to moderate regular physical activity. These participants were recruited from September 2020 to July 2021 at the University of Kiel, Germany.
Related StoriesBased on theoretical assumptions, a TEE of about 225 kcal/d was estimated due to the variations in CHO content between KETO and the isocaloric formula diet . However, such values were not achieved in the first 24 hours of KD intervention. A modest increase of about 100 kcal/d was observed in response to a KD. This could be due to the rise in energy-demanding pathways, such as hepatic gluconeogenesis and the triglyceride fatty acid cycle.
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