Researchers identify a specific genetic variant, rs2204985, linked to less severe lung involvement and a stronger immune response in COVID-19 patients with severe pneumonia. The study suggests that understanding this genetic marker could help identify high-risk individuals and enhance strategies for prevention and treatment.
By Vijay Kumar MalesuSep 25 2023Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Science Advances, a group of researchers investigated the influence of rs2204985 polymorphism within the T-cell receptor alpha and T-cell receptor delta locus on the immune response and severity of coronavirus disease 2019 in patients with severe pneumonia.
About the study The present study unfolded within the intensive care unit of Clinique Ambroise Paré in Neuilly, France, from March 2020 to February 2022, encompassing 40 adult COVID-19 patients and 41 control patients with non-COVID-19 related diseases. A subgroup consented to a second examination six months post-recovery. The control group, admitted during the same period, consisted of individuals hospitalized for varied medical reasons.
Statistical analyses, utilizing tests like analysis of variance and Mann-Whitney across diverse software tools, were employed to explore the complex interactions between SARS-CoV-2 and the human body. These comprehensive methodologies yielded significant insights into the virus's nature, enhancing understanding and facilitating the development of precisely targeted therapeutic interventions.
The rs2204985 genotype's association was investigated with levels of thymopoiesis in patients, and the data indicated that GG patients have a higher median signal-joint TREC/DJbeta TREC ratio compared to GA and AA individuals, signaling an efficient adaptive immune response against SARS-CoV-2 during acute infection. This reflected a more substantial thymic output correlated with a higher number of circulating T cells, crucial in the immune response against the virus.
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