CRISPR is a revolutionary tool that allows scientists to precisely modify the genome and gene expression of cells in any organism. It's a reagent-;a substance that facilitates a reaction-;that combines an enzyme with a programmable RNA capable of locating specific genetic sequences.
Lehigh UniversityOct 7 2024 CRISPR is a revolutionary tool that allows scientists to precisely modify the genome and gene expression of cells in any organism. It's a reagent-;a substance that facilitates a reaction-;that combines an enzyme with a programmable RNA capable of locating specific genetic sequences. Once guided to the correct spot, the enzyme acts like a pair of scissors, cutting, replacing, or deleting sequences of DNA .
Gonzalez-Fernandez and his team recently received a grant from the National Science Foundation to address this side effect, specifically when it comes to modifying genes for desired therapeutic outcomes.
Gonzalez-Fernandez credits Graham with incorporating machine learning into the project. The PhD student, who is supported by an NSF Graduate Research Fellowship, became intrigued by the potential of applying the technology after taking a machine learning course taught by Zhang. In order to function, however, CRISPR must penetrate a cell's nucleus. And so the second part of the NSF grant focuses on the side effects of how that machinery-;the enzyme and the RNA-;is delivered to cells via nanoparticle-based vehicles.
Gene Bioengineering Cancer Cartilage Cell Deep Learning DNA Enzyme Gene Expression Genes Genetic Genome Induced Pluripotent Stem Cells Machine Learning Nanoparticle Research RNA Stem Cells Technology Therapeutics
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