Ozempic, Wegovy Improve Sense of Taste, Aiding Weight Loss

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Ozempic, Wegovy Improve Sense of Taste, Aiding Weight Loss
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Semaglutide, found in weight loss drugs Ozempic and Wegovy, has been found to improve sensitivity to taste, perhaps explaining another way the medications help change food preferences and lead to weight loss.

June 4, 2024 – Sofia Spieler, a Boston public relations professional who has been losing weight on Wegovy, said her “snack monster” has essentially disappeared after she's had a lifelong sweet tooth.

These drugs, also known as GLP-1 receptor agonists, also changed gene expression in the tongue responsible for taste perception and changed the brain’s reward response to sweet tastes, researcher Mojca Jensterle Sever, PhD, of the University Medical Centre, Ljubljana, Slovenia, told those attending ENDO 2024, the annual Endocrine Society meeting, Saturday in Boston.

The researchers measured their taste sensitivity for 16 weeks, using taste strips with 4 concentrations of sweet, salty, and bitter tastes. Brain responses to a sweet solution dripping onto the tongue before and after a meal were measured with functional MRI. Small tissue samples were also taken from the women’s tongues.

Sever predicted her findings would ring true with obesity doctors as well as patients on the GLP-1 medications. But in an email interview, she said, “At this point, wegeneralize that those taking semaglutide may now perceive sweets in the same way as people who are not obese, and so do not crave sweets .”

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