Noveldrug shows promise for alleviating both heartfailure and the sleep apnea associated with it NatureComms
The echocardiographic evaluation was performed one day before the myocardial surgery , and repeated three days and seven weeks after the myocardial infarction in chronic HF rats. In juvenile rats, the echocardiographic analysis was performed ten days after the myocardial infarction. Rats were anesthetized with ketamine and Xylazine , and the depth of anesthesia was assessed frequently by a noxious pinch to the tail or a paw to check for a withdrawal response.
cDNA pre-amplification was performed in the single-cell RT-qPCR experiments using the TaqMan PreAmp Master Mix Kit using the P2X2 , P2X3 and β-actin probes. The reactions for the RT-qPCR were performed in singleplex and triplicate using the same probes described above and the TaqMan Universal PCR Master Mix kit according to the manufacture’s recommendations. β-actin was used as a house keeping control gene to normalize reactions. The relative quantitation was determined by the ΔΔCt method.
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