Pan-cancer T cell atlas reveals new details of tumormicroenvironment NatureMedicine
High-resolution spatial profiling image showing stressed T cells within the tumor microenvironment. T cells in stress response state are marked with white dots. The number of white dots within each cell denotes the abundance of the heat shock gene transcript, HSPA1A, a marker of stressed T cells. Credit: Yunhe Liu, Ph.D., The University of Texas MD Anderson Cancer Center
This new pan-cancer single-cell T cell atlas integrates 27 single-cell RNA sequencing datasets, including nine unique datasets from MD Anderson, covering 16 cancer types. It is the most detailed picture to date of the heterogeneity of T cells present within the tumor microenvironment and shows how their phenotypic states, as well as the relative proportions of each state, play a crucial role in determining the effectiveness of immunotherapy and the likelihood of potential adverse effects.
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