Pancreatic cancer has been dubbed a 'silent killer' due to how easy it is to overlook the symptoms
Jerry Springer has died at age 79 just a few months after being diagnosed with pancreatic cancer - known as the 'silent killer'.
It's not clear exactly when Springer was diagnosed with pancreatic cancer, but the statement explained that he suffered a "brief illness." Pancreatic cancer is often diagnosed at an advanced stage. Unfortunately, it can be pretty hard to spot and symptoms can often be overlooked - especially those less known - with some signs assumed to be other, less serious illnesses.
More commonly, the growing tumour may lead to tummy or back pain, which may feel worse when you're eating or lying down and better when you lean forward.
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ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA - Genome MedicineBackground Liquid biopsies and the dynamic tracking of somatic mutations within circulating tumour DNA (ctDNA) can provide insight into the dynamics of cancer evolution and the intra-tumour heterogeneity that fuels treatment resistance. However, identifying and tracking dynamic changes in somatic copy number alterations (SCNAs), which have been associated with poor outcome and metastasis, using ctDNA is challenging. Pancreatic adenocarcinoma is a disease which has been considered to harbour early punctuated events in its evolution, leading to an early fitness peak, with minimal further subclonal evolution. Methods To interrogate the role of SCNAs in pancreatic adenocarcinoma cancer evolution, we applied whole-exome sequencing of 55 longitudinal cell-free DNA (cfDNA) samples taken from 24 patients (including 8 from whom a patient-derived xenograft (PDX) was derived) with metastatic disease prospectively recruited into a clinical trial. We developed a method, Aneuploidy in Circulating Tumour DNA (ACT-Discover), that leverages haplotype phasing of paired tumour biopsies or PDXs to identify SCNAs in cfDNA with greater sensitivity. Results SCNAs were observed within 28 of 47 evaluable cfDNA samples. Of these events, 30% could only be identified by harnessing the haplotype-aware approach leveraged in ACT-Discover. The exceptional purity of PDX tumours enabled near-complete phasing of genomic regions in allelic imbalance, highlighting an important auxiliary function of PDXs. Finally, although the classical model of pancreatic cancer evolution emphasises the importance of early, homogenous somatic events as a key requirement for cancer development, ACT-Discover identified substantial heterogeneity of SCNAs, including parallel focal and arm-level events, affecting different parental alleles within individual tumours. Indeed, ongoing acquisition of SCNAs was identified within tumours throughout the disease course, including within an untreated metastatic tumour. Conclusions T
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