The Best in Science News and Amazing Breakthroughs
"Now that we know how Aplp1 and Lag3 interact, we have a new way of understanding how alpha-synuclein contributes to the disease progression of Parkinson's disease,""Our findings also suggest that targeting this interaction with drugs could significantly slow the progression of Parkinson's disease and other neurodegenerative diseases."
"Our work previously demonstrated that Lag3 wasn't the only cell surface protein that helped neurons absorb alpha-synuclein, so we turned to Aplp1 in our most recent experiments," The scientists conducted tests with genetically modified mice that were missing either Aplp1 or Lag3, or both. They found Aplp1 and Lag3 can each independently help brain cells absorb harmful alpha-synuclein, but together they significantly increase the uptake.
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
What ultimately happened to the USS Discovery in the 'Star Trek: Discovery' series finale?Richard's love affair with outer space started when he saw the original 'Star Wars' on TV aged four, and he spent much of the ’90s watching 'Star Trek”, 'Babylon 5” and “The X-Files' with his mum.
Read more »
Obesity-cancer connection discovery suggests strategies for improving immunotherapyImmune system cells called macrophages play an unexpected role in the complicated connection between obesity and cancer. The findings provide a mechanistic explanation for how obesity can contribute to both increased cancer risk and enhanced responses to immunotherapy.
Read more »
Strange Discovery Suggests Children Trust Robots Over HumansThe Best in Science News and Amazing Breakthroughs
Read more »
'Exciting' New Parkinson's Treatment May Cure Root Cause'It's the first drug ever to take a patient go from positive to negative,' Vaxxinity co-founder Lou Reese told Newsweek.
Read more »
Blood Biomarker Panel May Predict Parkinson's Years in AdvanceNew findings take the field of Parkinson's disease another step closer to the holy grail of early diagnosis before clinical symptoms and neuronal loss occur.
Read more »
New deep brain stimulation algorithm may help personalize Parkinson's disease treatmentDeep brain stimulation (DBS) has shown promise as a treatment for some symptoms of Parkinson s disease (PD). However, not all symptoms improve equally well with DBS. A better understanding of how different sites of electrical stimulation impact the wide range of motor symptoms associated with PD could help fine-tune treatment.
Read more »