In a groundbreaking new study, conducted within the framework of the FWF-funded Cluster of Excellence 'Microbiomes drive Planetary Health', scientists from the University of Vienna, in collaboration with the University of Southampton, Aalborg University and Boston University, have revealed that the widely prescribed Parkinson's disease drug...
University of ViennaNov 22 2024 In a groundbreaking new study, conducted within the framework of the FWF-funded Cluster of Excellence "Microbiomes drive Planetary Health", scientists from the University of Vienna, in collaboration with the University of Southampton, Aalborg University and Boston University, have revealed that the widely prescribed Parkinson's disease drug entacapone significantly disrupts the human gut microbiome by inducing iron deficiency.
A novel study design to investigate drug-bug interactions Using a novel experimental approach, the international team studied the effects of two drugs-;entacapone and loxapine, a medication for schizophrenia-;on fecal samples from healthy human donors.
"By showing that entacapone induces iron deficiency, we have uncovered a new mechanism of drug-induced gut dysbiosis, in which the drug selects for E. coli and other potentially pathogenic microbes well adapted to iron limiting conditions," said Michael Wagner, scientific director of the Excellence Cluster and vice-head of the Centre for Microbiology and Environmental Systems Science at the University of Vienna.
Microbiome Bacteria Drugs Dysbiosis E. Coli Fluorescence Imaging Large Intestine Microbiology Oligonucleotide Parkinson's Disease Research
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