Organoids, formed as intricate three-dimensional (3D) structures, hold the capacity to originate from a wide array of cellular sources, ranging from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) to somatic stem cells and even cancer cells.
Patient-derived organoids in human cancer: A platform for fundamental research and precision medicineThe GBM organoids culture process and subsequent analysis are illustrated schematically. A rapid and dependable technique has been described to create GBM organoids, confirmed by morphology and further verified with immunohistochemistry and immunofluorescence experiments.
The team also indicated that cancer PDOs effectively recapitulate the histopathologic characterization of parental tumors. Additionally, organoids do exhibit a degree of preservation of the genomic features found in their parental tumors, albeit with certain distinctions between them. Generally, a higher number of CAN and SNV genes were observed in the organoids compared to the parental tumors.
The team also revealed the potential of patient-derived tumor organoids in predicting the response of tumor patients to chemotherapy, radiotherapy, and targeted therapy. Despite the numerous advantages of organoids over other in vitro models, their use is still subject to limitations. This study was led by Dr. Shanqiang Qu and Rongyang Xu , and other members of the Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University.: Patient-derived organoids in human cancer: A platform for fundamental research and precision medicine retrieved 25 March 2024 from https://medicalxpress.com/news/2024-03-patient-derived-organoids-human-cancer.html
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