A multinational collaboration co-led by the Garvan Institute of Medical Research has uncovered a potential explanation for why some cancer patients receiving a type of immunotherapy called checkpoint inhibitors experience increased susceptibility to common infections.
Garvan Institute of Medical Research Nov 27 2024
Our findings indicate that while checkpoint inhibitors boost anti-cancer immunity, they can also handicap B cells, which are the cells of the immune system that produce antibodies to protect against common infections. This understanding is a critical first step in understanding and reducing the side effects of this cancer treatment on immunity.
Professor Tangye adds: "This dampening of the generation and quality of memory B cells could explain the increased rates of infection reported in patients with cancer receiving checkpoint inhibitor therapy." Co-senior author Dr Stéphanie Boisson-Dupuis, from Rockefeller University, says, "Although PD-1 inhibitors have greatly improved cancer care, our findings indicate that clinicians need to be aware of the potential trade-off between enhanced anti-tumor immunity and impaired antibody-mediated immunity."
Immunotherapy Antibodies Antibody Cancer Therapy Cancer Treatment Cell Genetic Immune System Immunity Immunology Medical Research Medicine PD-L1 Research
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