Randomized controlled trials, or RCTs, are believed to be the best way to study the safety and efficacy of new treatments in clinical research.
Michigan State UniversityJul 2 2024 However, a recent study from Michigan State University found that people of color and white women are significantly underrepresented in RCTs due to systematic biases.
The study, published in the Journal of Ethnicity in Substance Abuse, reviewed 18 RCTs conducted over the last 15 years that tested treatments for post-traumatic stress and alcohol use disorder. The researchers found that despite women having double the rates of post-traumatic stress and alcohol use disorder than men, and people of color having worse chronicity than white people, most participants were white and male .
Because RCTs are the gold standard for treatment studies and drug trials, we rarely ask the important questions about their limitations and failings. For RCTs to meet their full potential, investigators need to fix barriers to inclusion. Increasing representation in RCTs is not simply an issue for equity, but it is also essential to enhancing the quality of our science and meeting the needs of the public that funds these studies through their hard-earned tax dollars.
Furthermore, the journals publishing these studies did not have regulations requiring sample diversity, equity or inclusion as appropriate to the conditions under investigation. Related Stories"Marginalized groups have unique experiences from privileged groups, and when marginalized groups are poorly included in research, we remain in the dark about their experiences, insights, needs and strengths," said Mallet Reid, co-author of the study and doctoral candidate in MSU's Department of Psychology.
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New study finds systematic biases at play in clinical trialsRandomized controlled trials, or RCTs, are believed to be the best way to study the safety and efficacy of new treatments in clinical research. However, a recent study from Michigan State University found that people of color and white women are significantly underrepresented in RCTs due to systematic biases.
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