Explore why women may be at higher risk of developing mania and major depressive disorder during perimenopause.
By Dr. Sanchari Sinha Dutta, Ph.D.Reviewed by Lily Ramsey, LLMAug 19 2024 A study published in Nature Mental Health reveals that women may be at higher risk of developing mania and major depressive disorder during perimenopause, which is the period of time around menopause.
Only a handful of studies have suggested that perimenopause may increase the risk of developing psychiatric complications, including major depressive disorder, schizophrenia spectrum disorders, and bipolar disorder. Study design The UK Biobank data was analyzed in the study, which included information on menopausal timing and psychiatric history of 128,294 female participants. This information was collected through interviews conducted by trained nurses and self-reported online questionnaires.
Related StoriesAmong study participants, about 0.59% reported their first onset of a psychiatric disorder during the premenopausal period, 0.88% reported the same during the perimenopausal period, and 0.50% reported the same during the postmenopausal period . The incidence rate of mania returned to the premenopausal level during postmenopause. However, for major depressive disorder, a significantly lower incidence rate was observed during postmenopause compared to that during premenopause.
The observed association between perimenopause and increased incidence rates of psychiatric disorders remained unchanged after adjusting for potential confounding factors, including material deprivation, physical health status, obesity, alcohol intake frequencies, and previous or never smoking habits.
Mania Aging Bipolar Disorder Depressive Disorder Major Depressive Disorder Menopause Mental Health Ovaries Schizophrenia Sleep Stress UK Biobank
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