A new editorial paper was published in Oncoscience, titled 'PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors; PARs.'
While targeted cancer therapy is greatly dependent on specific oncogenic pathways or conferred by genetic alterations, it remains challenging and somewhat disappointing. The high level of failure relies on the interplay between the dose for desired therapy versus toxicity, namely the therapeutic index. Furthermore, one should take into consideration resistance response that develops with time to a given drug, contributing immensely to the given drawback.
"TCGA and GTEx database show that PAR2/F2RL1 is significantly overexpressed in many types of epithelial malignancies among of which are colon, breast and ovarian cancers," conclude the authors.: PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors retrieved 24 May 2024 from https://medicalxpress.com/news/2024-05-ph-motifs-platform-drug-lessons.html
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