Findings indicate a serine/glycine-free diet can reduce colorectal cancer growth and enhance immune response, offering insights for immunotherapy strategies.
By Dr. Liji Thomas, MDReviewed by Danielle Ellis, B.Sc.Nov 29 2024 Early trial shows a specialized diet enhances immune cell activity and improves the effectiveness of immunotherapy in colorectal cancer patients
Altering the immune state and the tumor microenvironment could enhance the efficacy of immunotherapy. One way to achieve this is to deprive the tumor of nutrients. Prior studies have explored the impact of a serine/glycine-free diet . However, not much is known about how this affects colorectal cancer incidence or mortality rates. This spurred the present study, which examines the impact of the -SG diet on the TME on CRC growth and cell-mediated antitumor immunity, focusing on tumor-infiltrating cytotoxic T cells.
-SG diet and T cells The -SG diet altered the TME and renewed cell-mediated antitumor immune responses. It promotes and augments T cell receptor diversity and antigen specificity, thus inducing a strong T cell response to specific tumor cell epitopes. Cytotoxic T cells accumulated in the tumor, Increased lactate concentrations in hypoxic conditions induced PD-L1 lactylation within the tumor cells. This increases PD-L1 levels by inhibiting its breakdown by lysosomes. This is thus a negative regulatory mechanism.
Conclusions A serine/glycine-free diet reduces tumor growth and strengthens the immune-mediated killing of tumor cells by inducing a robust T-cell response to tumor neoantigens.
Colorectal Colorectal Cancer Diet Glycine Immune Response Serine Cell Cell Metabolism Cytotoxicity Efficacy Immunity Immunotherapy In Vitro Ligand Metabolism MMR PD-L1 Phenotype T-Cell Tumor
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