The ASUNCTIS trial evaluated asunercept's safety and efficacy in COVID-19, showing trends toward faster recovery despite not meeting statistical significance.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMNov 18 2024 While the trial confirmed asunercept’s safety and tolerability, it failed to achieve statistically significant improvement in clinical outcomes compared to standard care.
Emerging variants with increased transmissibility or immune escape further compound the challenge. CD95L is implicated in lung injury and immune dysregulation, contributing to ARDS and poor prognosis. Patients were randomly assigned to receive standard of care alone or SOC plus one of three weekly intravenous doses of asunercept .
Results were analyzed in modified intent-to-treat and per-protocol populations, with exploratory analyses conducted for lymphocyte recovery and subgroup effects. The trial was monitored by an independent Data Safety Monitoring Board to ensure safety and protocol adherence. Improvements were observed more frequently in the asunercept groups than in the SOC group . Median time to clinical improvement was shorter in all asunercept arms compared with SOC , confirmed by Kaplan–Meier analysis and Cox regression models.
Covid-19 Efficacy Acute Respiratory Distress Syndrome Compound Coronavirus Intensive Care Laboratory Ligand Lymphocyte Mortality Pneumonia Protein Respiratory SARS SARS-Cov-2 Syndrome
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