Researchers reviewed the potential therapeutic effects of phytochemicals on the gut-brain axis, finding they could influence brain function and reduce neurological symptoms by modulating gut microbiota.
By Tarun Sai LomteMay 26 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Current Developments in Nutrition , researchers summarized the potential therapeutic implications of phytochemicals on the gut-brain axis .
Gut microbiota enzymes modify polyphenols by adding hydroxyl groups and removing sugar and methyl groups, leading to smaller compounds with improved intestinal absorption. Further, curcumin exhibits anticancer, anti-inflammatory, and antioxidant properties. However, its pharmacological benefits are limited by its chemical instability, low water solubility, poor bioavailability, and rapid metabolism.
Effects of apigenin and quercetin Apigenin is a pharmacologically active plant flavone used to treat different diseases. A study reported that a three-month apigenin treatment in mice with AD had improved memory retention and learning deficits. Further, treatment positively affected amyloid precursor protein processing and reduced amyloid-beta accumulation.
Effects of resveratrol and ginsenoside Rg1 Treatment with ginsenoside Rg1, the active component of ginseng, was shown to reduce the loss of dopamine neurons, behavior effects, and abnormal structural changes in the substantia nigra pars compacta. Resveratrol is a natural polyphenol with anti-inflammatory and anti-aging properties that can counteract stress. Studies have illustrated its impact on metabolic and CNS disorders, including obesity, dementia, depression, and diabetes.
Gut-Brain Axis Anti-Inflammatory Antioxidant Anxiety Autism Curcumin Depression Immune System Metabolite Metabolites Migraine Multiple Sclerosis Nanoparticles Nutrition Parkinson's Disease Polyphenol Protein Quercetin Resveratrol Sclerosis Stress
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