University of Pittsburgh scientists independently validated a new blood test platform that can simultaneously measure more than a hundred biomarkers of Alzheimer's disease.
University of PittsburghOct 9 2024 University of Pittsburgh scientists independently validated a new blood test platform that can simultaneously measure more than a hundred biomarkers of Alzheimer's disease. The platform might improve clinicians' ability to capture the multifaceted nature of Alzheimer's pathology and streamline early disease diagnostics. The report was published in Molecular Neurodegeneration today.
Capturing a detailed snapshot of molecular changes in the brains of individuals at risk of Alzheimer's disease who are not yet experiencing any cognitive or memory changes would allow scientists to track disease progression over time and, eventually, develop guidelines for early intervention. For a proof-of-concept study, Karikari and his team tested blood samples from a cohort of 113 cognitively normal older adults living in an economically underserved region in Southwestern Pennsylvania.
Related StoriesThe performance of the NULISA platform was independently validated against a series of assays of classical Alzheimer's biomarkers for each individual sample. Changes in biomarker profiles over two years were also compared with imaging-based measures of amyloid, tau and neurodegeneration.
Blood Biomarker Blood Test Brain Cell Diagnostics Nerve Neurodegeneration Pathology Ph Psychiatry Research
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