Pomegranate peel extract effectively restores skin microbiota balance by reducing Staphylococcus aureus and promoting Staphylococcus epidermidis growth, showcasing its potential as a non-toxic antimicrobial treatment.
By Dr. Sanchari Sinha Dutta, Ph.D.Aug 5 2024 A study published in the journal PLOS ONE describes the effectiveness of pomegranate peel extract in restoring the skin microbiota homeostasis through its antimicrobial action against Staphylococcus aureus.
In healthy skin microbiota, S. hominis, S. lugdunensis, and S. epidermidis exert antimicrobial effects against the Gram-positive bacteria S. aureus. Any perturbation of skin microbial homeostasis can lead to dysbiosis, which is characterized by a reduced abundance of beneficial microbes like S. epidermidis and an increased abundance of pathogenic microbes like S. aureus.
Study design The scientists collected skin microbiota samples from six healthy volunteers and three volunteers with atopic dermatitis. Among isolated bacterial colonies, they selected S. epidermidis and S. aureus for further experiments. The phytochemical analysis of pomegranate peel extract identified catechin, quercetin, vanillic acid, and gallic acid as the main bioactive compounds.
Related StoriesThe findings showed that the extract significantly increased the biofilm formation ability of S. epidermidis and significantly reduced the biofilm formation ability of S. aureus. Biofilm formation is a complex process in which microorganisms adopt a multicellular behavior that facilitates and prolongs their survival in diverse environmental niches.
Atopic Dermatitis Bacteria Dermatitis Dysbiosis Ph Quercetin Staphylococcus Aureus
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