Study indicates that older women with type 2 diabetes have a higher risk of fractures primarily due to impaired physical function rather than reduced bone density, despite stronger bone structure.
By Dr. Liji Thomas, MDReviewed by Benedette Cuffari, M.Sc.Aug 8 2024 A new paper in JAMA Network Open determines whether type 2 diabetes mellitus increases the risk of fractures in older women.How does diabetes affect other organs? Diabetes affects over 500 million individuals worldwide, and its prevalence is expected to continue to rise. Only about 4% of these individuals are diagnosed with type 1 diabetes mellitus , whereas the remaining 96% of people with diabetes are diagnosed with T2DM.
About the study The current study included 3,008 women between 75 and 80 years of age. These individuals were part of the Sahlgrenska University Hospital Prospective Evaluation of Risk of Bone Fractures study, which prospectively evaluates the risk of bone fractures in older women. What did the study show? Higher bone strength Related StoriesA total of 294 women in the study cohort had T2DM, of whom the mean age was 78 years. The T2DM group had 9% higher body weight, 19% higher body mass, and 6.3% greater limb lean mass.
Cortical area and density at the tibia were higher in women with T2DM. Trabecular bone volume fraction was also 8.7% higher in this group, thus suggesting better bone microarchitecture. Stiffness and ultimate failure load were higher at all bone sites in the T2DM group. T2DM and physical function Physical function measures were globally impaired in women with T2DM, who had about 10% weaker grip strength, 10% slower walking speed, and 14% slower to get up and start moving compared to controls. Prolonged treatment and insulin use were associated with worse physical function despite better bone measures.
Fracture Type 2 Diabetes Bone Bone Marrow Cardiovascular Disease Diabetes Mellitus Glycation Hip Fracture Insulin Micro Mortality Neuropathy Osteoporosis Renal Failure Research Retinopathy Type 1 Diabetes
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