Posttransplant Skin Disease: Consider Skin Cancer, Infection Risks

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Posttransplant Skin Disease: Consider Skin Cancer, Infection Risks
Malignant Skin NeoplasmBasal Cell CarcinomaBasal Cell Carcinoma Of The Skin
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Recent research sheds light on varying skin cancer risk, and a predictive tool offers guidance on screening in solid organ transplant recipients.

SAN DIEGO — The number of solid organ transplant survivors is on the rise, a dermatologist told colleagues, and they face unique challenges from higher risks for skin cancer and skin infections because of their suppressed immune systems.

Christensen encouraged dermatologists to be aware of the varying risks for immunosuppressive drugs and best screening practices for these patients, and to take advantage of a validated skin cancer risk assessment tool for transplant patients.), which cause severe immune suppression and pose a severe skin cancer risk. They may also cause gingival hyperplasia and sebaceous hyperplasia.

Transplant recipients with SCC, he said, have a twofold to threefold higher risk for metastasis and twofold to fivefold higher risk for death from SCC. have been linked in studies to a higher risk for nonmelanoma skin cancer. Moreover, new medications for treating GVHD have been linked to an increased risk for SCC, including a 3.2-fold increased risk for SCC associated with ruxolitinib, a Janus kinase 1 and JAK2 inhibitor, inChristensen also noted the higher risk for infections in immunocompromised patients and added that these patients can develop inflammatory disease despite immunosuppression:More than 80% of transplant recipients develop molluscum and verruca vulgaris/human papillomavirus infection.

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Malignant Skin Neoplasm Basal Cell Carcinoma Basal Cell Carcinoma Of The Skin Basal Cell Skin Cancer Basal Cell Epithelioma BCC Basal Cell Carcinoma (BCC) BCC - Basal Cell Carcinoma Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Cancer Risk Metastasis Metastatic Carcinoma Metastatic Cancer Metastases Transplantation Of An Organ Organ Transplantation

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