❌ “mRNA vaccines are not recommended for pregnant women or those who are breastfeeding” - Andrew Bridgen MP at PMQs This is not true. The Covid vaccines Mr Bridgen is referring to *are* recommended during (and after) pregnancy.
advised that pregnant women should be offered the Covid-19 vaccine at the same time their age group was.
The MHRA added: “Since then new data has come to light which supports the updated advice on vaccinating those who are pregnant and breastfeeding.which states that the vaccines are safe to use during pregnancy and breastfeeding.
In other words, this is an old document, from before there was lots of real-world data about the vaccine being safe for pregnant women.The document says it was “updated 16 August 2022”, which seems to have caused some confusion with people thinking it has only just been published. This document itselfto have been updated, but it is part of a group of documents concerning regulatory approval of the Pfizer vaccine, which features another document that has been updated.
The MHRA told Full Fact that the 16 August update “refers to changes made to the Summary of Product Characteristics and Patient Information Leaflet, which are found on the
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Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines - Genome MedicineBackground COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. However, little is known about the epigenetic alterations that occur in these cells during hyperinflammatory responses in severe COVID-19 patients. Methods In this study, we obtained the DNA methylome and transcriptome of peripheral blood monocytes from severe COVID-19 patients. DNA samples extracted from CD14 + CD15- monocytes of 48 severe COVID-19 patients and 11 healthy controls were hybridized on MethylationEPIC BeadChip arrays. In parallel, single-cell transcriptomics of 10 severe COVID-19 patients were generated. CellPhoneDB was used to infer changes in the crosstalk between monocytes and other immune cell types. Results We observed DNA methylation changes in CpG sites associated with interferon-related genes and genes associated with antigen presentation, concordant with gene expression changes. These changes significantly overlapped with those occurring in bacterial sepsis, although specific DNA methylation alterations in genes specific to viral infection were also identified. We also found these alterations to comprise some of the DNA methylation changes occurring during myeloid differentiation and under the influence of inflammatory cytokines. A progression of DNA methylation alterations in relation to the Sequential Organ Failure Assessment (SOFA) score was found to be related to interferon-related genes and T-helper 1 cell cytokine production. CellPhoneDB analysis of the single-cell transcriptomes of other immune cell types suggested the existence of altered crosstalk between monocytes and other cell types like NK cells and regulatory T cells. Conclusion Our findings show the occurrence of an epigenetic and transcriptional reprogramming of peripheral blood monocytes, which could be associated with the
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