A study published in Clinical Epigenetics finds that prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobehavioral development that may influence longer-term offspring outcomes.
]. Altogether, studies from this field of research suggest that neurobehavioral disorders such as ASD, likely originate with dysregulated placental function.
Although the current evidence is not sufficient to conclude that prenatal cannabis exposure is a cause or a risk factor for development of ASD in offspring, there are a few large cohort studies that examine long-term outcomes related to prenatal cannabis exposure longitudinally.
Another recent study assessed the effects of maternal cannabis use on psychosocial and physiological measures in young children along with the potential relevance of the in utero environment reflected in the placental transcriptome []. This study identified a relationship between maternal cannabis use and transcriptome changes in the placenta as a potential mediator of risk for anxiety-related problems in early childhood.
Strengths of our study are that it utilized a translational rhesus macaque model to overcome the limitations of existing studies such as the inability to measure cannabis exposure including timing, duration, frequency, dose, type of product, and administration route.
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