A randomized clinical trial published in JAMA Network Open found no significant overall benefit of maternal progesterone therapy on neurodevelopmental outcomes in infants with congenital heart defects, but observed improvements in female children and specific heart conditions.
By Dr. Sanchari Sinha Dutta, Ph.D.Jun 2 2024 Scientists at the University of Pennsylvania, USA, have conducted a randomized clinical trial to investigate the impact of maternal progesterone therapy on neurodevelopmental outcomes in infants with congenital heart defects.Study: Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects. Image Credit: adriaticfoto / Shutterstock
In this randomized clinical trial, scientists have assessed the impact of prenatal progesterone therapy on neurodevelopmental outcomes in fetuses with congenital heart defects. Important observations The analysis of baseline characteristics revealed that about 50% of fetuses have hypoplastic left heart syndrome, 37% have transposition of the great arteries, and the rest have other types of congenital heart defects.
Progesterone therapy was found to significantly improve motor scores in female children and those with other types of congenital heart defects than hypoplastic left heart syndrome and transposition of the great arteries. A significant improvement in language scores was also observed in progesterone-exposed female children.
Progesterone Brain Children Clinical Trial Genetic Hormone Hypoplastic Hypoplastic Left Heart Syndrome Language Metabolites Microcephaly Mortality Placebo Progenitor Cells Steroid Syndrome Vaginal
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